Preventing opioid overdose deaths with take-home naloxone
11 de Outubro de 2016
Individuals who overdose on heroin or other opioids classically receive treatment when the
ambulance or emergency medical care arrives, at which point the opioid antagonist
naloxone is typically given. Naloxone is a semi-synthetic competitive opioid antagonist,
which reverses opioid overdose and has been used in clinical and hospital overdose
management since the 1970s. However, over the past 20 years, the provision of naloxone
kits to opioid users and others likely to witness opioid overdoses has emerged as a novel
harm-reduction intervention to make the antidote available in situations of need. Several
countries in Europe and elsewhere have introduced take-home naloxone programmes that
combine provision of the antidote with training in overdose prevention and emergency
management. In November 2014, the World Health Organization (WHO) released new
guidelines, recommending that take-home naloxone should be made available to anyone
likely to witness an overdose.
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