Dysfunction of the prefrontal cortex in addiction
19 de Outubro de 2017
Abstract | The loss of control over drug intake that occurs in addiction was initially believed
to result from disruption of subcortical reward circuits. However, imaging studies in addictive
behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its
regulation of limbic reward regions and its involvement in higher-order executive function
(for example, self-control, salience attribution and awareness). This Review focuses on
functional neuroimaging studies conducted in the past decade that have expanded our
understanding of the involvement of the PFC in drug addiction. Disruption of the PFC in
addiction underlies not only compulsive drug taking but also accounts for the
disadvantageous behaviours that are associated with addiction and the erosion of free will.
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