Validation and application for the synthetic cannabinoids
18 de Setembro de 2014
Validation and application of an UPLC–MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market
Over de last decade, the abuse of herbal blend incense products and other ‘‘legal high’’ products, such as powders and pills containing ‘‘designer drugs’’ available to purchase on the Internet and in various head shops, has increased. Since the introduction into the market in 2004 as ‘‘legal highs’’ the synthetic cannabinoids have gained popularity first in Europe but rapidly spread all over the world. The synthetic cannabinoids are synthesized in laboratories and are formulated to interact with the endogenous cannabinoid receptors (CB1 and CB2) in the brain to produce psychoactive cannabis-like effects that have been reported to include acute adverse effects, such us, agitation, anxiety, confusion, hypertension, sedation, psychosis, hallucinations, tachycardia, and seizures.
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