Methadone induces testosterone suppression in patients with opioid addiction
18 de Setembro de 2014
Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence.
Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the
association between testosterone and addictive behaviour in opioid dependence. Although opioid use has
been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to
methadone treatment for opioid dependence is unclear. The present multi-centre cross-sectional study
consecutively recruited 231 patients with opioid dependence from methadone clinics across Ontario,
Canada between June and December of 2011. We obtained demographic details, substance use, psychiatric
history, and blood and urine samples from enrolled subjects.
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