THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction
29 de Dezembro de 2017
Recent evidence has implicated the endocannabinoid (eCB) system in nicotine addiction. The eCB system also has an important
role in reward mechanisms, and nicotine addiction has been associated with aberrant reward processing. Motivated by this
evidence, we tested the hypothesis that eCB modulation of reward processing is altered in subjects with a nicotine addiction
(NAD). For this purpose, we compared reward-related activity in NAD with healthy controls (HC) in a pharmacological magnetic
resonance imaging (MRI) study using D9-tetrahydrocannabinol (THC) administration to challenge the eCB system.
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