Dorsolateral Prefrontal Cortex Activity and Neuromodulation in Crack-Cocaine Dependents during Early Abstinence
11 de Outubro de 2016
The mesocorticolimbic dopamine system and the nigrostriatal
dopamine system both contribute to cue-induced cocaine seeking
[1-3] and other behavioral effects of cocaine, including cocaine reward
[4,5]. It is well known that areas from prefrontal cortex (PFC) that are
involved in these drug-related processes are activated when drug
addicted are exposed to either the drug or some drug-cue [6-14]
postulated that this enhanced activity of PFC could contribute to the
compulsive self-administration and the lack of control (impaired
inhibition) in addicted subjects and also contribute to disruptive
cognitive operations that impair judgment and favor relapse [14].
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